Publications‎ > ‎

Dr. Castro's Publications (selected from >200)

  • Calinescu, AA, Núñez, FJ, Koschmann, C, Kolb, BL, Lowenstein, PR, Castro, MG.  (2015) Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma. Journal of Visualized Experiments, February 22, 2015.  PMCID: PMC4354658.

  • Mineharu Y, Kamran N, Lowenstein PR, and Castro MG.  (2014) Blockade of mTOR signaling via Rapamycin Combined with Immunotherapy Augments Anti-glioma Cytoxic and Memory T cells’ functions.  Molecular Cancer Therapeutics, December 13, 2014; (12):3024-36.  PMCID: PMC4258521.
  • Candolfi M, Yagiz K, Wibowo M, Ahlzadeh G, Puntel M, Kamran N, Paran C, Ghiasi H, Lowenstein PR, Castro MG. (2014) Temozolomide does not impair gene therapy-mediated antitumor immunity in syngenic brain tumor models.  Clinical Cancer Research. March 15, 2014;20(6):1555-65.  Epub February 5, 2014.  Portrayed on the cover of the March, 2014 issue. PMCID: PMC3959570.
  • Castro MG, Lowenstein PR. (2013) Neuro-oncology:  The long and winding road --gene therapy for gliomaNature Reviews Neurology 2013 November; 9(11):  609-10.  Epub 2013 September 24.  PMCID: PMC3928109.

  • Candolfi M, King GD, Yagiz K, Curtin JF, Mineharu Y, Muhammad AG, Foulad D. Kroeger KM, Josien R, Lowenstein PR, and Castro, MG.  (2012) Plasmacytoid Dendritic Cells in the Tumor Microenvironment:  Immune Targets for Glioma Therapeutics. Neoplasia, 2012 Aug; 14(8):757-70.  PMCID:  PMC3431182.
  • Yang J, Sanderson N, Wawrowsky K, Castro MG, Lowenstein PR. (2010) Kupfer-type immunological synapses are not relevant to cytolytic T-cell function in vivo. Proceedings of the National Academy of Sciences, USA 107(10):4716-4721. PMCID: PMC2842057.
  • Larocque D, Sanderson NRS, Bergeron J, Curtin J, Girton J, Wibowo M, Bondale N, Kroeger KM, Yang J, Lacayo LM, Reyes KC, Farrokhi C, Pechnick RN, Castro MG, Lowenstein PR, (2010) Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology. Proceedings of the National Academy of Sciences, USA. 107(32):14443-14448. PMCID: PMC2922551.
  • Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, Foulad D, Lowenstein PR, Castro MG. (2010) Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics. Proceedings of the National Academy of Sciences, USA, 107(46):20021-20026. Epub 2010 Oct 28. PMCID: PMC2993419.
  • Muhammad AKM, Puntel M, Candolfi M, Salem A, Yagiz K, Farrokhi C, Kroeger KM, Xiong W, Curtin JF, Liu C, Lawrence K, Bondale NS, Lerner J, Baker GJ, Foulad D, Pechnick RN, Palmer D, Ng P, Lowenstein PR, Castro MG. (2010) Study of the Efficacy, biodistribution and safety profile of therapeutic gutless adenovirus vectors as a prelude to a Phase 1 Clinical Trial for Glioblastoma. Clinical Pharmacology & Therapeutics, 88(2):204-213. PMCID:  PMC2908190.
  • Curtin JF, Liu N, Candolfi M, Ziong W, Assi H, Yagiz Y, Michelsen K, Kroeger K, Liu C, Muhammad A, Arditi M, Comin-Anduix B, Ribas A, Lowenstein PR, Castro MG. (2009) HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS Medicine Jan 13; 6(1):e10; PMCID: PMC2621261.
  • Candolfi M, Yagiz K, Foulad D, Alzadeh GE, Tesarfreund M, Muhammad AKM, Puntel M, Kroeger KM, Liu C, Lee S, Curtin J, King GD, Lerner J, Sato K, Lowenstein PR, Castro MG. (2009) Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. Clinical Cancer Research 15(13):4401-4414. Portrayed on the Highlights Section. PMCID: PMC2769255.
  • Ali S, King G, Curtin J, Candolfi M, Xiong W, Liu C, Puntel M, Cheng Q, Prieto J, Ribas A, Kupiec-Weglinski J, van Rooijen N, Lassman H, Lowenstein PR, Castro MG. (2005) Combined immuno-stimulation and conditional cytotoxic gene therapy provide long term survival in a large glioma model.  Cancer Research. August 15, 2005; 65(16):7194-7204.  Portrayed on the highlights section of Cancer Research.  PMCID:  PMC1242178.
  • Umana P, Gerdes CA, Stone D, Davis JR, Ward D, Castro MG, Lowenstein PR (2001) Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination. Nature Biotechnology, 19:582-585.  PMID: 11385466.
  • Thomas CE, Schiedner G, Kochanek S, Castro MG, Lowenstein PR (2000) Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first generation, but not with high-capacity adenovirus vectors: towards realistic long-term neurological gene therapy for chronic diseases. Proceedings of the National Academy of Sciences, USA, 97:7482-7487.  PMCID: PMC16571.
  • Dewey RA, Morrissey G, Cowsill C, Stone D, Dodd NJF, Bolognani F, Southgate TD, Klatzmann D, Castro MG, Lowenstein PR. (1999) Chronic brain inflammation and persistent HSV1-TK expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials. Nature Medicine, November, 1999;5(11), 1256-1263 Portrayed on the cover of the journal.  PMID 10545991.

 

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