Publications‎ > ‎

Dr. Lowenstein's Publications (selected from >200)

  • Baker GJ, Castro MG, and Lowenstein PR. (2015) Isolation and Flow Cytometric Analysis of Glioma-Infiltrating Peripheral Blood Mononuclear Cells.  Journal of Visualized Experiments, Epub 28 Nov 2015.

  • Baker G, Chockley P, Yadav V, Doherty R, Ritt M, Sivaramakrishnan S, Castro MG, Lowenstein PR.  (2014) Natural killer cells eradicate galectin-1 deficient glioma in the absence of adaptive immunity.  Cancer Research, 74:5079-90.  PMCID:  PMC4184887.
  • Baker GJ, Yadav VN, Motsch S, Koschmann C, Calinescu A, Mineharu Y, Carmelo-Piragua S, Orringer D, Bannykh S, Nicholas WS, deCarvalho AC, Mikkelsen T, Castro MG, Lowenstein PR. (2014) Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-independent Vascularization and Resistance to Anti-angiogenic Therapy.  Neoplasia. 16:543-561. Portrayed on the cover of the July, 2014 issue. PMID: 25117977.
  • Lynes J, Wibowo M, Koschmann C, Baker G, Saxena V, Ghulam Muhammad AK, Bondale N, Klein J, Assi H, Lieberman P, Castro MG, Lowenstein PR.  (2014) Lentiviral-Induced High-Grade Gliomas in Rats: The Effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H.  Neurotherapeutics, 11:623-35.  PMCID: PMC4121445.
  • Castro MG, Lowenstein PR. (2013) Neuro-oncology:  The long and winding road --gene therapy for gliomaNature Reviews Neurology 2013 November; 9(11):  609-10.  Epub 2013 September 24.  PMCID: PMC3928109.

  • Sanderson NS, Puntel M, Kroeger KM, Bondale NS, Swerdlow M, Iranmanesh N, Yagita H, Ibrahim A, Castro MG, Lowenstein PR,  (2012) Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.  The Proceedings of the National Academy of Sciences, USA.  109(20):  7835-40.  PMCID:  PMC3356634.
  • Zirger JM, Puntel M, Bergeron J, Wibowo M, Moridzadeh R, Bondale N, Barcia C, Kroeger KM, Liu C, Castro MG, Lowenstein PR. (2012) Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells. Molecular Therapy, 20:808-19.  PMCID:  PMC3321600.
  • Larocque D, Sanderson NRS, Bergeron J, Curtin J, Girton J, Wibowo M, Bondale N, Kroeger KM, Yang J, Lacayo LM, Reyes KC, Farrokh C, Pechnick RN, Castro MG, Lowenstein PR, (2010) Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology. The Proceedings of the National Academy of Sciences, USA, 107:14443-14448.  PMCID: PMC2922551.
  • Yang J, Sanderson N, Wawrowsky K, Castro MG, Lowenstein PR. (2010) Kupfer-type immunological synapses are not relevant to cytolytic T-cell function in vivo. Proceedings of the National Academy of Sciences, USA 107:4716-21 Portrayed on the cover.   PMCID: PMC2842057.
  • Mineharu Y, King G, Muhammad AKM, Bannykh S, Kroeger K, Liu C, Lowenstein PR, Castro MG.  (2011)  Engineering the brain tumor microenvironment enhances the efficacy of dendritic cells' vaccination: implications for clinical trials design. Clinical Cancer Research 17: 4705-4718.
  • Curtin JF, Liu N, Candolfi M, Ziong W, Assi H, Yagiz Y, Edwards MR, Michelsen KS, Kroeger KM, Liu C, Muhammad AK, Clark MC, Arditi M, Comin-Anduix B, Ribas A, Lowenstein PR, Castro MG. (2009) HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS Medicine, 6:e10.  PMCID: PMC2621261.
  • Ghulam Muhammad AK, Candolfi M, King GD, Foulad D, Yagiz K, Mineharu Y, Kroeger K, Treuer KA, Nichols WS, Sanderson NS, Lowenstein PR, Castro MG. (2009) Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression Clinical Cancer Research 15:6113-6127. PMCID:  PMC2796687.
  • Barcia C, Wawrowsky K, Barrett RJ, Liu C, Castro MG, Lowenstein PR, (2008) In vivo polarization of IFN-g at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells. The Journal of Immunology, 180:1344-1352. Portrayed on the cover; PMCID: PMC2629497.
  • Barcia C, Thomas C, Curtin J, King G, Wawrowsky K, Candolfi M, Kroeger K, Boyer O, Kupiec-Weglinski J, Klatzmann D, Castro MG, Lowenstein PR, (2006) In Vivo mature effector immunological synapses forming supramolecular activation cluster (SMAC) mediate clearance of virally infected astrocytes from the brain.  The Journal of Experimental Medicine 203(9):2095-2107 Portrayed on the cover, reviewed in detail by Science, Cell, and Faculty of 1000-Biology.  PMCID: PMC1997281.
  • Ali S, King GD, Curtin JF, Candolfi M, Xiong W, Liu C, Puntel M, Cheng Q, Prieto J, Ribas A, Kupiec-Weglinski J, van Rooijen N, Lassman H, Lowenstein PR, Castro MG. (2005) Combined immuno- stimulation and conditional cytotoxic gene therapy provide long term survival in a large glioma model.  Cancer Research, 65:7194-7204.  Portrayed on the highlights section of Cancer Research.  PMCID: PMC1242178.
  • Umana P, Gerdes CA, Stone D, Davis JR, Ward D, Castro MG, Lowenstein PR. (2001) Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination. Nature Biotechnology, 19:582-585.  PMID: 11385466.
  • Thomas CE, Scheidner G, Kochanek S, Castro MG, Lowenstein PR. (2000) Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first generation, but not with high-capacity adenovirus vectors: toward realistic long- term neurological gene therapy for chronic diseases. Proceedings of the National Academy of Sciences, USA 97:7482-7487.  PMCID: PMC16571.
  • Dewey R, Morrissey G, Cowsill C, Stone D, Dodd N, Southgate T, Klatzmann D, Lassmann H, Castro MG, Lowenstein PR. (1999) Chronic brain inflammation and persistent HSV-1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials. Nature Medicine, 5:1256-1263. Portrayed on cover.  PMID:  10545991.